2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W016009S2
    2'-Deoxyadenosine-5'-monophosphate-15N5 dilithium 98%
    2'-Deoxyadenosine-5'-monophosphate-15N5 dilithium is 15N labeled 2'-Deoxyadenosine-5'-monophosphate (HY-W016009). 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
    2'-Deoxyadenosine-5'-monophosphate-15N5 dilithium
  • HY-W016009S3
    2'-Deoxyadenosine-5'-monophosphate-13C10 dilithium 98%
    2'-Deoxyadenosine-5'-monophosphate-13C10 dilithium is 13C-labeled 2'-Deoxyadenosine-5'-monophosphate (HY-W016009). 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
    2'-Deoxyadenosine-5'-monophosphate-13C10 dilithium
  • HY-W016009S4
    2'-Deoxyadenosine-5'-monophosphate-13C10,15N5 dilithium 2483830-51-7 98%
    2'-Deoxyadenosine-5'-monophosphate-13C10,15N5 dilithium is 13C and 15N-labeled 2'-Deoxyadenosine-5'-monophosphate (HY-W016009). 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
    2'-Deoxyadenosine-5'-monophosphate-13C10,15N5 dilithium
  • HY-W016562S3
    Hippuric acid-15N 93627-88-4 98%
    Hippuric acid-15N is the 15N-labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.
    Hippuric acid-15N
  • HY-W017018S1
    L-Ornithine-1,2-13C2 hydrochloride 224054-19-7 98%
    L-Ornithine-1,2-13C2 (hydrochloride) is the 13C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
    L-Ornithine-1,2-13C2 hydrochloride
  • HY-W017443S3
    L-Asparagine-15N2,d3 monohydrate 98%
    L-Asparagine-15N2,d3 monohydrate is the deuterium and 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine-15N2,d3 monohydrate
  • HY-W017443S4
    L-Asparagine-1,2,3,4-13C4 monohydrate 768348-44-3 98%
    L-Asparagine-1,2,3,4-13C4 monohydrate is the 13C labeled labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine-1,2,3,4-13C4 monohydrate
  • HY-W017522S5
    Adipic acid-d4-1 19031-55-1 98%
    Adipic acid-d4-1 (Hexanedioic acid-d4-1) is the deuterium labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc.
    Adipic acid-d4-1
  • HY-W017522S6
    Adipic acid-13C2 133954-44-6 98%
    Adipic acid-13C2 (Hexanedioic acid-13C2) is 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc.
    Adipic acid-13C2
  • HY-W021425S1
    D-Mannosamine-d2 hydrochloride 98%
    D-Mannosamine-d2 (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal-d2) hydrochloride is a deuterium labeled D-Mannosamine hydrochloride (HY-W021425). D-Mannosamine is a six-carbon glycoamine that is an amino derivative of D-mannose. D-mannoamine plays a variety of important biological roles in cells.
    D-Mannosamine-d2 hydrochloride
  • HY-W030796AR
    Lactisole (Standard) 150436-68-3
    Bisdemethoxycucurmin (Standard) is the analytical standard of Bisdemethoxycucurmin. This product is intended for research and analytical applications. Bisdemethoxycucurmin (Curcumin III), a curcuminoid, has antioxidant and antiinflammatory activities.
    Lactisole (Standard)
  • HY-W032013S1
    1-Octanol-d2 78510-02-8 98%
    1-Octanol-d2 is the deuterium labeled 1-Octanol. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents. 1-Octanol is a highly attractive biofuel with diesel-like properties.
    1-Octanol-d2
  • HY-W040329S2
    2'-Deoxyadenosine-d13 98%
    2'-Deoxyadenosine-d13 is deuterium labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
    2'-Deoxyadenosine-d13
  • HY-W040329S3
    2'-Deoxyadenosine-15N5,d13 98%
    2'-Deoxyadenosine-15N5,d13 is deuterium and 15N labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
    2'-Deoxyadenosine-15N5,d13
  • HY-W013061S10
    Propane-1,2,3-triyl tripalmitate-13C 98%
    Propane-1,2,3-triyl tripalmitate-13C is the 13C labeled Propane-1,2,3-triyl tripalmitate. Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
    Propane-1,2,3-triyl tripalmitate-13C
  • HY-10869
    OL-135 681135-77-3 98%
    OL-135 is a CNS penetrant, selective, and reversible of FAAH inhibitor. OL-135 exhibits analgesic activity.
    OL-135
  • HY-11085
    T-226296 331758-35-1 98%
    T-226296 is an oral active and selective melanin-concentrating hormone receptor antagonist with the IC50 values of 5.5 nM and 8.6 nM for human SLC-1 and rat SLC-1, respectively. T-226296 can be used for study of obesity and insulin resistance.
    T-226296
  • HY-12074
    Cazpaullone 914088-64-5 98%
    Cazpaullone is a glycogen synthase kinase-3 (GSK-3) inhibitor. Cazpaullone can activate pancreatic beta cell protection and replication. Cazpaullone can be used for the research of diabetes.
    Cazpaullone
  • HY-12104
    PF-514273 851728-60-4 98%
    PF-514273 is an orally active, selective antagonist for cannabinoid-1 receptor (CB1) with IC50 of 1 nM. PF-514273 reduces the food uptake in mice, and can be used for obesity research.
    PF-514273
  • HY-12735
    SCH 900822 1220894-09-6 98%
    SCH 900822 is a potent and selective glucagon receptor (hGCGR) antagonist that blocks the binding of glucagon to its receptor, thereby reducing hepatic glycogenolysis and gluconeogenesis, thereby lowering blood glucose production. SCH 900822 can be used in the study of type 2 diabetes.
    SCH 900822
Cat. No. Product Name / Synonyms Application Reactivity